BODY WEIGHTS AND WORK PERFORMANCE OF ADRENALECTOMIZED RATS TREATED WITH PROGESTERONE, Δ417 A-METHYL-D-HOMO-ANDROSTENE-17 A-OL,-3, 17-DIONE, AND 6-HYDROXY-11-DESOXYCORTICOSTERONE DIACETATE1

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Abstract
Several steroid compounds were examined for possible effects upon the body-wt. and work performance of adrenalectomized rats. Large doses of progesterone enabled the animals to gain wt. and perform more work than untreated animals but the work performance remained very inferior to that of normal animals. Progesterone, 17 ([beta]) hydroxy-progesterone, and 6-hydroxy-progesterone acetate all failed to enhance the work performance of adrenalectomized rats when the test was conducted immediately following operation. The compound [DELTA]4-17a-methyl-D-homo-androstene-17a-ol-3,17-dione was without a positive effect on either body wt. or work. The compound 6-hydroxy-ll-desoxycor-ticosterone diacetate did not enhance the work performance of rats tested immediately following adrenalectomy but in larger dosage it enabled rats to gain wt. following adrenalectomy. It was definitely less active in this respect than 11-desoxycorticosterone acetate.
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