Human Regulatory Gene for Inducible Tyrosine Aminotransferase in Rat-Human Hybrids
- 1 April 1973
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 70 (4) , 1268-1272
- https://doi.org/10.1073/pnas.70.4.1268
Abstract
The inducibility of tyrosine aminotransferase (EC 2.6.1.5) by corticosteroid hormones in rat-human hybrid clones was studied. The presence of human X chromosome activity in the cells was always associated with the suppression of tyrosine aminotransferase inducibility in all the clones examined. Negative correlation between the human X chromosome and inducibility of the enzyme was clearly established. Corticosteroid receptor was present to the same extent in hybrid cell clones that either contained or lost the human X chromosome. The human repressor for inducible tyrosine aminotransferase has a linkage relationship with glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and hypoxanthine-guanine-phosphoribosyltransferase (EC 2.4.2.8) and, therefore, can be assigned to the X chromosome.Keywords
This publication has 18 references indexed in Scilit:
- Isoenzymes of hypoxanthine-guanine-phosphoribosyl transferase in a family with partial deficiency of the enzymeBiochemical Genetics, 1972
- Somatic Cell Genetic Assignment of Peptidase C and the Rh Linkage Group to Chromosome A-1 in ManScience, 1972
- Cellular Site of Glucocorticoid-Receptor Complex FormationScience, 1972
- Cytological Mapping of Human X-Linked Genes by Use of Somatic Cell Hybrids Involving an X-Autosome TranslocationProceedings of the National Academy of Sciences, 1972
- Expression of Differentiated Functions in Hepatoma Cell Hybrids: Reappearance of Tyrosine Aminotransferase Inducibility after the Loss of ChromosomesProceedings of the National Academy of Sciences, 1971
- Simplicity of Mammalian Regulatory Systems inferred by Single Gene Determination of Sex PhenotypesNature, 1971
- Expression of Tyrosine Aminotransferase Activity in Somatic-Cell Heterokaryons: Evidence for Negative Control of Enzyme ExpressionProceedings of the National Academy of Sciences, 1971
- A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMESThe Lancet, 1971
- Control of Specific Gene Expression in Higher OrganismsScience, 1969
- Induction of tyrosine alpha-ketoglutarate transaminase by steroid hormones in a newly established tissue culture cell line.Proceedings of the National Academy of Sciences, 1966