Autoantibody inhibits binding of von Willebrand factor to glycoprotein Ib and collagen in multiple myeloma

Abstract
A 49-year-old man with multiple myeloma (IgG-Λ, Bence-Jones protein positive) presented a bleeding tendency: characterized intramuscular hemorrhage. Coagulation studies showed a von Willebrand factor (vWF) defect (Duke bleeding time > 20 min; ristocetin cofactor activity [vWF:RC]

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