Stimulation of steroid glucuronidation by uridine diphosphate N-acetylglucosamine and by microsomal disruption
- 15 October 1977
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 168 (1) , 125-127
- https://doi.org/10.1042/bj1680125
Abstract
Glucuronidation of oestrone and of oestradiol in microsomal fractions was markedly and significantly stimulated by UDP-N-acetylglucosamine and by ultrasonication: Triton X-100 also stimulated. This is consistent with compartmentation of UDP-glucuronyl-transferase. Stimulation by UDP-N-acetylglucosamine may be physiologically significant.Keywords
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