Human RhoGAP domain‐containing proteins: structure, function and evolutionary relationships
- 11 September 2002
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 528 (1-3) , 27-34
- https://doi.org/10.1016/s0014-5793(02)03331-8
Abstract
Proteins containing a RhoGAP (Rho GTPase activating protein) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these regulators of the actin cytoskeleton. Using database searches, at least 53 distinct RhoGAP domain-containing proteins are likely to be encoded in human DNA. Phylogenetic analysis of only the RhoGAP domains divides these proteins into distinct families that appear to be functionally related. We also review the current understanding of the structure and likely functions of these human proteins. The presence of RhoGAP domains in a number of different human proteins suggests that cytoskeletal changes, regulated by Rho GTPase, may be integrated with many different signaling pathways.Keywords
This publication has 76 references indexed in Scilit:
- Small interfering RNAs as a tool to assign Rho GTPase exchange-factor function in vivoBiochemical Journal, 2002
- Generation of high curvature membranes mediated by direct endophilin bilayer interactionsThe Journal of cell biology, 2001
- Isolation of a Novel Human Gene, ARHGAP9, Encoding a Rho-GTPase Activating ProteinBiochemical and Biophysical Research Communications, 2001
- p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculationNature Cell Biology, 2001
- Initial sequencing and analysis of the human genomeNature, 2001
- Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAPNature Structural & Molecular Biology, 1998
- p190-B, a New Member of the Rho GAP Family, and Rho Are Induced to Cluster after Integrin Cross-linkingJournal of Biological Chemistry, 1995
- Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleusCell, 1992
- Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinasesCell, 1991
- Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region geneJournal of Molecular Biology, 1990