Pancreatic secretory trypsin inhibitor (PSTI) isolated from pig intestine Influence on insulin and somatostatin release
- 9 April 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 281 (1-2) , 227-230
- https://doi.org/10.1016/0014-5793(91)80399-n
Abstract
Upon investigation of pig intestinal peptides for effects on the relcuse of endocrine hormones from the isolated perfused rat pancreas, we reported earlier that glucose‐stimulated insulin release was inhibited by PEC‐60, a peptide with marked sequence similarity to PSTI (pancreatic secretory trypsin inhibitor). Continuing this study we found a polypeptide, which inhibited glucose‐induced insulin release but enhanced glucose‐induced somatostatin secretion. Determination of the amino acid sequence of this polypeptide revealed that it is identical to that of PSTI. Thus, PSTI modulates islet hormone release.Keywords
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