On the Value of the Activated Partial Thrombo-Plastin Time (APTT) in Monitoring Heparin Therapy
- 1 January 1976
- journal article
- research article
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 35 (03) , 592-597
- https://doi.org/10.1055/s-0038-1647957
Abstract
Summary: Of 1068 blood samples referred for evaluation of the haemostatic mechanism 135 contained heparin as judged by the polybrene titration method. Of the 57 samples with a heparin concentration in the defined therapeutic range, 65 per cent had APTT values in the “therapeutic range”. Of the samples from patients who had not received any anticoagulant, 213 (24 per cent) had prolonged APTT, and 48 of these samples had APTT values in the “therapeutic range” for heparin therapy. It is suggested that the APTT test is of limited value in monitoring heparin therapy.This publication has 3 references indexed in Scilit:
- Antiheparin activity of some human blood protein fractions and their possible relationship to thrombosisJournal of Clinical Pathology, 1965
- The Partial Thromboplastin Time with Kaolin: A Simple Screening Test for First Stage Plasma Clotting Factor DeficienciesAmerican Journal of Clinical Pathology, 1961
- Heparin Tolerance and the Plasma ProteinsScandinavian Journal of Clinical and Laboratory Investigation, 1961