Phase I-II Trials of Poly(ICLC) in Malignant Brain Tumor Patients
- 1 January 1982
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 2 (1) , 1-4
- https://doi.org/10.1089/jir.1982.2.1
Abstract
Poly(ICLC) preparation, containing poly-L-lysine and poly(I) • poly(C) at a weight ratio of 1:2, was given intravenously at a dose of 0.05 to 0.2 mg/kg to 7 patients with malignant brain tumor. Poly(ICLC) induced significant serum interferon (more than 100 reference units/ml) in all patients. The highest interferon titer induced was 875 reference units/ml. Severe side effect was not observed except fever. Hypotension, leukopenia and elevation of liver enzyme levels were observed as side effects in a few cases.Keywords
This publication has 8 references indexed in Scilit:
- Modified polyriboinosinic-polyribocytidylic acid complex: modulation of toxicity for rabbits by alterations in componentsAntimicrobial Agents and Chemotherapy, 1980
- Interferon Production in Human Diploid Cell Strains Derived from Embryonic LungsMicrobiology and Immunology, 1980
- Modified polyriboinosinic-polyribocytidylic acid complex: induction of serum interferon, fever, and hypotension in rabbitsAntimicrobial Agents and Chemotherapy, 1980
- Modified polyriboinosinic-polyribocytidylic acid complex: sustained interferonemia and its physiological associates in humansInfection and Immunity, 1979
- Interferon Induction in Cynomolgus and Rhesus Monkeys After Repeated Doses of a Modified Polyriboinosinic-Polyribocytidylic Acid ComplexAntimicrobial Agents and Chemotherapy, 1977
- A Phase I–II Trial of Multiple-Dose Polyriboinosinic-Polyribocytidylic Acid in Patients With Leukemia or Solid TumorsJNCI Journal of the National Cancer Institute, 1976
- A Modified Polyriboinosinic-Polyribocytidylic Acid Complex That Induces Interferon in PrimatesThe Journal of Infectious Diseases, 1975