Immunoblastic Sarcoma

Open Access
Publisher Website
Google Scholar
Abstract
Kurtz, Donald M.: Immunoblastic sarcoma. Am J Clin Pathol 67:227–229, 1977. A systemic, malignant disorder of immunoblasts has been reported to occur as a late transition phase of immunoblastic lymphadenopathy in an older population.5 With a background of polyclonal gammopathy, drug sensitivity, lupus erythematosus or rheumatoid arthritis, there may develop a progressive “cloning out” of monomorphous immunoblasts to form immunoblastic sarcoma. Recently, a 17-year-old, postpartum girl without these bizarre hypersensitivity phenomena developed a rapidly fatal, systemically malignant process with severe clinical complications. No historical incitent was identified. The pregnancy had been uneventful and birth had produced a thriving, viable infant. This case may represent the youngest patient with primary, malignant immunoblastic disease occurring in the absence of a “hypersensitivity” state. A brief discussion of the clinical situation, management, and autopsy findings is presented. Basic morphologic criteria for proper differentiation of malignant immunoblastic problems, lymphoma, and Hodgkin’s disease are discussed.

This publication has 0 references indexed in Scilit: