SAR by MS: A Ligand Based Technique for Drug Lead Discovery Against Structured RNA Targets
- 27 July 2002
- journal article
- letter
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 45 (18) , 3816-3819
- https://doi.org/10.1021/jm0255466
Abstract
A technique for lead discovery vs RNA targets utilizing mass spectrometry (MS) screening methods is described. The structure−activity relationships (SAR) derived from assaying weak binding motifs allows the pharmacophores discovered to be elaborated via “SAR by MS” to higher affinity ligands. Application of this strategy to a subdomain of the 23S rRNA afforded a new class of compounds with functional activity.Keywords
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