Imaging Transgenic Animals
- 1 August 1999
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biomedical Engineering
- Vol. 1 (1) , 611-648
- https://doi.org/10.1146/annurev.bioeng.1.1.611
Abstract
▪ Abstract Transgenic and eugenic animals as small as 30 g can be studied noninvasively by radionuclides with resolutions of 1–2 mm, by MRI with resolution of 100 μm and by light fluorescence and bioluminescence with high sensitivities. The technologies of radionuclide emission, magnetic resonance imaging, magnetic resonance spectroscopy, optical tomography, optical fluorescence and optical bioluminescence are currently being applied to small-animal studies. These technologies and examples of their applications are reviewed in this chapter.Keywords
This publication has 112 references indexed in Scilit:
- Initial results from the Sherbrooke avalanche photodiode positron tomographIEEE Transactions on Nuclear Science, 1996
- Development of central 5-HT2A receptor radioligands for PET: Comparison of [3H]RP 62203 and [3H]SR 46349B kinetics in rat brainNuclear Medicine and Biology, 1996
- In vivo evaluation of [11C]-and [18F]-labelled cocaine analogues as potential dopamine transporter ligands for positron emission tomographyNuclear Medicine and Biology, 1996
- Myocardial infarction in rats: high-resolution single-photon emission tomographic imaging with a pinhole collimatorEuropean Journal of Nuclear Medicine and Molecular Imaging, 1996
- Alteration of Intracellular Metabolite Diffusion in Rat Brain In Vivo During Ischemia and ReperfusionStroke, 1995
- Cerebral Energy Metabolism and Immediate Early Gene Induction Following Severe Incomplete Ischaemia in Transgenic Mice Overexpressing the Human Ornithine Decarboxylase Gene: Evidence that Putrescine is not Neurotoxic In VivoEuropean Journal of Neuroscience, 1995
- Distribution of cocaine recognition sites in rat brain: In vitro and ex vivo autoradiography with [125I]RTI-55Journal of Chemical Neuroanatomy, 1994
- Application of Localized In Vivo NMR to Whole Organ Physiology in the AnimalAnnual Review of Physiology, 1992
- Anisotropy in diffusion‐weighted MRIMagnetic Resonance in Medicine, 1991
- FLASH imaging. Rapid NMR imaging using low flip-angle pulsesJournal of Magnetic Resonance (1969), 1986