Agents that elevate platelet cAMP stimulate the formation of phosphatidylinositol 4‐phosphate in intact human platelets
- 20 January 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 195 (1-2) , 115-118
- https://doi.org/10.1016/0014-5793(86)80142-9
Abstract
The present study investigates the effect of compounds that are known to elevate cAMP on the phospholipid metabolism of platelets. Prostaglandin E1, forskolin and isobutylmethylxanthine induce an increase in [32P]‐phosphatidylinositol 4‐phosphate (PIP) in platelets prelabelled with [32P]orthophosphate. Possible roles of this phenomenon are discussed in view of the inhibitory effect of cAMP elevation on platelet activation.Keywords
This publication has 29 references indexed in Scilit:
- Tumour‐promoting phorbol esters inhibit agonist‐induced phosphatidate formation and Ca2+ flux in human plateletsFEBS Letters, 1985
- Regulation of plasma membrane Ca2+ ATPases by lipids of the phosphatidylinositol cycleBiochemical and Biophysical Research Communications, 1984
- Cyclic AMP-dependent protein kinase stimulates the phosphorylation of phosphatidylinositol to phosphatidylinositol-4-monophosphate in a plasma membrane preparation from pig granulocytesBiochemical and Biophysical Research Communications, 1984
- Phorbol myristate acetate stimulates formation of phosphatidyl inositol 4-phosphate and phosphatidyl inositol 4,5-bisphosphate in human plateletsBiochemical and Biophysical Research Communications, 1984
- 1-Oleoyl-2-acetyl-glycerol (OAG) stimulates the formation of phosphatydylinositol 4-phosphate in intact human plateletsBiochemical and Biophysical Research Communications, 1984
- Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slicesBiochemical and Biophysical Research Communications, 1984
- 12‐O‐Tetradecanoylphorbol 13‐acetate stimulates inositol lipid phosphorylation in intact human plateletsFEBS Letters, 1984
- Cytoplasmic Ca2+ in platelets is controlled by cyclic AMP: Antagonism between stimulators and inhibitors of adenylate cyclaseBiochemical and Biophysical Research Communications, 1984
- The cytoplasmic concentration of free calcium in platelets is controlled by stimulators of cyclic AMP production (PGD2, PGE1, forskolin)Biochemical and Biophysical Research Communications, 1983
- Phosphatidylinositol-specific phospholipase-C of platelets: Association with 1,2-diacylglycerol-kinase and inhibition by cyclic-AMPBiochemical and Biophysical Research Communications, 1979