Clear Cell Sarcoma of Tendons and Aponeuroses and Malignant Blue Nevus Arising in Prepubescent Children Report of Two Cases and Review of the Literature

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Abstract
The low incidence of malignant melanoma in children makes the diagnosis of this disease problematic for clinicians and pathologists. The diagnosis becomes especially difficult when the melanoma is a rare variant of conventional melanoma, such as clear cell sarcoma of tendons and aponeuroses (CCSTA), and malignant blue nevus (MBN). In this report we describe two prepubescent children, one with a MBN, and one with CCSTA. The patient with MBN also developed acute lymphoblastic leukemia, and died of metastatic malignant melanoma within 1 year of diagnosis. We present the histological and clinical features of these cases and review the literature on these rare tumors arising in prepubescent children.

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