DIABETOGENIC ACTION OF HUMAN GROWTH HORMONE Synthesis and Activity of C-terminal Fragments
- 1 February 1979
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 13 (2) , 195-200
- https://doi.org/10.1111/j.1399-3011.1979.tb01868.x
Abstract
Three peptides corresponding to the C-terminal region of human growth hormone have been synthesized by the solid-phase method: HGH-(177–191), HGH-(178–191) and HGH-(179–191). The diabetogenic activities of these synthetic peptides are reported. The data indicate that extension of HGH-(179–191) at its NH2-terminus is required for in vivo activity. The reduced and S-carbamido-methylated form of HGH-(177–191) was also active, indicating that the disulphide bond is possibly not a prerequisite for biological activity.Keywords
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