Functionalisation of saturated hydrocarbons. Part 13. Further studies on the Gif oxidation of cholestane derivatives
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 3,p. 463-468
- https://doi.org/10.1039/p19890000463
Abstract
The oxidation of cholest-4-en-3-one by the GifIVsystem to give progesterone has been studied over the temperature range –40 to +80 °C. The optimum temperature is +20 °C. Below 0 °C the yield of progesterone diminishes and the formation of a new compound, 25-hydroxycholest-4-en-3-one, is observed. The latter has been synthesised from lithocholic acid. An unexpected major product of the oxidation was A-nor-5β-cholestan-3-one, identified by comparison with an authentic sample.Keywords
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