Simple synthesis of trifluoromethylated pyrimidine nucleosides
- 1 January 1977
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 15,p. 536-537
- https://doi.org/10.1039/c39770000536
Abstract
Treatment of 2′,3′,5′-tri-O-acetyl-5-iodouridine and 3′,5′-di-O-acetyl-5-iododeoxyuridine with trifluoromethyl iodide and copper powder gave the corresponding 5-trifluoromethyluridine derivatives; this is the first example of direct trifluoromethylation of nucleosides.This publication has 2 references indexed in Scilit:
- Synthesis of Fluorinated Pyrimidines and Triazines1,2Journal of Medicinal Chemistry, 1966
- Syntheses of 5-Trifluoromethyluracil and 5-Trifluoromethyl-2'-deoxyuridine1,2Journal of Medicinal Chemistry, 1964