CELLULAR AND PLASMA KINETICS OF DAUNORUBICIN GIVEN BY 2 METHODS OF ADMINISTRATION IN A PATIENT WITH ACUTE-LEUKEMIA

  • 1 January 1982
    • journal article
    • research article
    • Vol. 66  (12) , 2085-2088
Abstract
Leukemic cell and plasma concentrations of daunorubicin were examined serially in a patient with acute lymphoblastic leukemia following administration of the drug by the following 2 different regimens: Regime A, an i.v. bolus dose of 50 mg/m2; and regimen B, a loading dose of 15 mg/m2 followed by 35 mg/m2 infused over 4 h. Peak plasma levels were 4 times higher after regimen A than B; leukemic cell concentrations were not significantly different. No difference in acute toxicity or therapeutic efficacy was seen after either method of administration. However, peak plasma levels of daunorubicin apparently can be reduced by continuous infusion without significantly altering target tissue concentrations.

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