A new in vivo model for the evaluation of topical antiseptics on superficial wounds. The effect of 70% alcohol and povidone-iodine solution

Publisher Website
Google Scholar
Abstract
A preliminary evaluation of the antiseptic activity of 70% alcohol and 10% providone-iodine solution was carried out in an animal model. After the inoculation of partial-thickness wounds with Staphylococcus aureus, 0.1 ml of the antiseptic agent (70% alcohol or providone-iodine solution) was rubbed into the wound for 30 s. The agent was left on the wound for 1 min, 3 min and 24 h; the wounds were then cultured for bacteria. After 1 min, the treatments did not reduce the number of pathogens. After 3 min, 70% alcohol and povidone-iodine solution produced a slight reduction; after 24 h, povidone-iodine solution slightly reduced the number of pathogenic bacteria that could be cultured. After 24 h, neither agent reduced the number of pathogens below 105 colony-forming units/ml. Evidently, single applications of 70% alcohol or povidone-iodine may have very limited efficacy as antiseptic agents for the treatment of superficial wounds.

This publication has 1 reference indexed in Scilit: