[3H]-Thymidine Uptake and Lipid Peroxidation by Tumor Cells on Embelin Treatment: An in vitro Study
- 1 January 1995
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 52 (1) , 66-68
- https://doi.org/10.1159/000227430
Abstract
Using a rapid technique to assess drug-induced cell toxicity, a fibrosarcoma cell line was exposed in vitro to increasing concentrations of embelin, a benzo-quinone derivative of Embelia ribes Burm., and simultaneously inoculated with [3H]-thymidine. After regular time intervals, the cells were examined for incorporation of the labelled thymidine in DNA, lipid peroxide and glutathione levels. A dose-dependent decrease in labelled thymidine uptake, lipid peroxide and glutathione levels was observed on embelin administration.Keywords
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