Effect of Saralasin in Hypertensive Patients on Chronic Hemodialysis

Publisher Website
Google Scholar
Abstract
Hypertension in patients on chronic hemodialysis is thought to be largely of 2 types: volume dependent or renin dependent. If renin dependent hypertension is mediated by angiotensin II, then angiotensin II antagonism should lower blood pressure. To test this hypothesis, the angiotensin II antagonist saralasin was given to 15 hypertensive patients on chronic hemodialysis. Patients were separated into 2 groups by their blood pressure response. In responders blood pressure was 191/112 mm Hg and fell to 147/85 during saralasin administration (P < 0.01). Nonresponders had blood pressures of 190/111 mm Hg before and 188/110 during saralasin administration. Five responders subsequently had nephrectomies with normalization of their blood pressures. Plasma renin activity averaged 70 ng/ml .cntdot. 3 h of angiotensin I in responders and increased to 110 after saralasin (P < 0.05), while nonresponders had values of 21 before and after saralasin. Renin dependent hypertension apparently is an important mechanism in certain patients on chronic hemodialysis, and such pateints respond to angiotensin II antagonism.

This publication has 3 references indexed in Scilit: