Metabolic Characterization of the R6/2 Transgenic Mouse Model of Huntington's Disease by High-Resolution MAS1H NMR Spectroscopy
- 21 January 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Proteome Research
- Vol. 5 (3) , 483-492
- https://doi.org/10.1021/pr050244o
Abstract
The metabolic consequences of Huntington's disease in the R6/2 mouse model were investigated using NMR spectroscopy and pattern recognition to characterize selected brain regions, muscle, blood, and urine. Global increases in relative brain concentrations of osmolytes, creatine, glutamine, and lactate, and decreases in acetate and N-acetylaspartate were found together with striatal-specific lower concentrations of GABA and choline. Clear differentiation of R6/2 and wild-type mice was also obtained for urine and blood metabolite profiles that may have applicability for monitoring HD in human populations. Keywords: Huntington's disease • metabolic profiling • NMR spectroscopy • pattern recognition • R6/2 miceKeywords
This publication has 51 references indexed in Scilit:
- Metabolic characterization of distinct neuroanatomical regions in rats by magic angle spinning 1H nuclear magnetic resonance spectroscopyMagnetic Resonance in Medicine, 2005
- Deranged neuronal calcium signaling and Huntington diseasePublished by Elsevier ,2004
- Metabolic Profiling of the Effects ofd-Galactosamine in Liver Spheroids Using1H NMR and MAS-NMR SpectroscopyChemical Research in Toxicology, 2002
- Spectral profiles of cultured neuronal and glial cells derived from HRMAS 1H NMR spectroscopyNMR in Biomedicine, 2002
- Alterations in the Mouse and Human Proteome Caused by Huntington's DiseaseMolecular & Cellular Proteomics, 2002
- Metabonomics: a platform for studying drug toxicity and gene functionNature Reviews Drug Discovery, 2002
- High‐resolution 1H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2‐bromoethanamine in intact renal and hepatic tissueMagnetic Resonance in Medicine, 2001
- Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic MiceCell, 1996
- Proton magnetic resonance spectroscopy in Huntington's disease: Evidence in favour of the glutamate excitotoxic theory?Movement Disorders, 1996
- Diabetes mellitus in Huntington diseaseClinical Genetics, 1985