SURVIVAL DIFFERENCES EXHIBITED BY NORMAL AND TRANSFORMED RAT-LIVER EPITHELIAL-CELL LINES IN AGGREGATE FORM

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (6) , 1864-1867
Abstract
Normal and transformed rat liver epithelial cell lines exhibited differences in the ability to survive in the aggregate form. Normal rat liver epithelial cells in the aggregate form underwent a rapid decline in the number of viable cells, while counterpart transformed epithelial cells exhibited an ability to survive and proliferative in the aggregate form. This survival ability correlated with colony formation in soft agar and tumorigenicity in nude mice. Cell survival in the aggregate form could possibly serve as a criterion for in vitro transformation of epithelial cells derived from rat liver.

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