The design of membrane-controlled transdermal therapeutic systems containing molsidomine.
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 35 (8) , 3407-3412
- https://doi.org/10.1248/cpb.35.3407
Abstract
A basic investigation aimed at developing a membrane-controlled transdermal therapeutic system was carried out. The drug used was molsidomine with oleic acid and propylene glycol as the absorption enhancer and the vehicle, respectively. It was concluded that a microporous polyethylene membrane was most suitable for release control. A desirable pattern of the molsidomine plasma concentration versus time curve could be obtained by controlling the amounts of the three components, molsidomine,oleic acid, and propylene glycol in the device. Furthermore, the plasma concentration of molsidomine was well sustained by adding polyethyleneglycol 400 to the oleic acid-propylene glycol solution.This publication has 2 references indexed in Scilit:
- Enhancement of percutaneous absorption of molsidomine.CHEMICAL & PHARMACEUTICAL BULLETIN, 1987
- Moment Analysis for the Separation of Mean In Vivo Disintegration, Dissolution, Absorption, and Disposition Time of Ampicillin ProductsJournal of Pharmaceutical Sciences, 1982