Effects of some bile acids on biliary flow and composition in dogs

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Abstract
Effects of some bile acids on the biliary flow, BSP [bromsulfophthalein] output and composition (phospholipid, cholesterol, bilirubin and bile acids) were studied in dogs. Ursodeoxycholic acid (UD), chenodeoxycholic acid (CD) and dehydrocholic acid (DC) caused a dramatic increase in biliary flow and BSP output. Relative potencies of these effects were DC > CD .gtoreq. UD. UD increased the phospholipid, bile acids and cholesterol concentration but had little effect on bilirubin concentration. UD greatly increased the output of 4 bile components. CD slightly decreased the phospholipid, cholesterol and bilirubin concentration without the bile acids, while CD increased the output of bile components. After UD or CD administration, the bile acid of each appeared markedly in the bile, dose dependently. DC caused a dramatic decrease of phospholipid, cholesterol and bilirubin concentration but had little effect on bile acids concentration. Output of bile components was increased by DC the first 1 h but decreased at 2 h. After DC administration, 3.alpha., 7.alpha.-dihydroxy-12keto-5.beta.-cholanic acid appeared in the bile while DC did not. UD and CD are cholanereticas and DC is a hydrocholeretica.