Vitamin K‐dependent carboxylase: Synthesis of an inhibitor of the glutamyl binding site
- 7 February 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 152 (1) , 79-82
- https://doi.org/10.1016/0014-5793(83)80486-4
Abstract
Liver microsomes contain a vitamin K and O2‐dependent carboxylase that converts peptide‐bound glutamyl residues to γ‐carboxyglutamyl residues. The peptide Boc‐O‐phospho—Ser‐O‐phospho—Ser—Leu‐OMe has now been synthesized. This peptide inhibits the carboxylation of endogenous protein precursors by a detergent‐solubilized preparation of the carboxylase and is an apparent competitive inhibitor of the carboxylation of Phe—Leu—Glu—Glu—Leu.Keywords
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