SV40-Transformed Human Diploid Cells that Remain Transformed throughout Their Limited Lifespan

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Abstract
Of 91 subcultured foci of SV40-transformed WI-38 human diploid fibroblasts, none yielded cells that grew indefinitely, but all cells in each subculture continued to produce T [tumor] antigen and to look morphologically transformed throughout their lifespan. These results are consistent with the commitment theory of fibroblast senescence, but predict that a special transformation event is necessary to account for the rare survivors.