OSCILLATORY POTENTIALS OF MUDPUPPY RETINA

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 17  (12) , 1176-1188
Abstract
The properties of the oscillatory potentials (OPs) of the mudpuppy electroretinogram (ERG) were studied and compared with the properties of the b-wave of the ERG and the proximal negative response (PNR). Both transretinal and intraretinal ERG were recorded in response to full-field as well as 200 and 500 .mu.m spot illumination. The OPs differed in behavior from the b-wave in terms of voltage-response relations and the effects of repetitive stimuli. Thus the OPs appear to have a different origin from that of the b-wave. The laminar profile of the OPs was also compared with both the PNR and the b-wave. The OPs reverse in polarity as a function of retinal depth and therefore appear to reflect radial flows of currents within the retina. Thus the origin of the OPs seems different also from that of the PNR, which appears to represent tangential current flows around the amacrine cells. The earlier OPs arise more proximally within the retina than the later ones, suggesting that the individual oscillatory peaks are likely to have different origins. The OPs may represent feedback loops within retina. The OPs were selectively depressed by GABA, glycine, glutamate and dopamine. Acetylcholine and carbacholine did not affect the oscillatory responses, suggesting perhaps that the OPs are generated by inhibitory feedback synaptic circuits.

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