ANTIBIOTIC-RESISTANT MUTANTS OF MYCOPLASMA-PNEUMONIAE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 16  (3) , 169-173
Abstract
Sensitivity tests of M. pneumoniae to antibiotics were performed with 28 strains to determine the minimum inhibitory concentration (MIC) of the antibiotics, the MIC after 14 days'' incubation at 37.degree. C, and the minimum plasmacidal concentration. The antibiotics tested were erythromycin, tetracycline, oxytetracycline, chloramphenicol and streptomycin. The MIC of erythromycin was around 0.01 .mu.g/ml, whereas that of tetracycline was approximately 0.1 .mu.g/ml. Of the 28 strains tested, 9 isolates gave rise to mutants resistant to high concentrations of erythromycin, chloramphenicol and streptomycin; none of the strains produced mutants resistant to tetracycline. Of the 9 resistant mutants, 3 strains were isolated from erythromycin-treated patients. One strain, isolated from a patient treated with erythromycin for 18 days, was resistant to the antibiotic in a concentration > 100 .mu.g/ml.

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