Relationship of CSF pH, O2, and CO2 responses in metabolic acidosis and alkalosis in humans

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Abstract
The effect of induced metabolic acidosis (48 h of NH4Cl ingestion, BE [base excess] - 10.6 .+-. 1.1) and alkalosis (43 h of NaHCO3- ingestion, BE + 8.8 .+-. 1.6) on arterial and lumbar CSF pH, PCO2 [CO2 partial pressure] and HCO3- and ventilatory responses to CO2 and to hypoxia was assessed in 5 healthy men. In acidosis lumbar CSF pH rose 0.033 .+-. 0.02 (P < 0.05). In alkalosis CSF pH was unchanged. Ventilatory response lines to CO2 at high O2 were displaced to the left in acidosis (9.0 .+-. 1.4 torr) and to the right in alkalosis (4.5 .+-. 1.5 torr) with no change in slope. The ventilatory response to hypoxia (.DELTA..ovrhdot.V40) was increased in acidosis (P < 0.05) and it was decreased in 4 subjects in alkalosis (P, not significant). Altered ventilatory drives of steady-state metabolic imbalance are mediated by peripheral chemoreceptors. In acidosis the medullary respiratory chemoreceptor drive is decreased.

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