Changes in mammographic breast density and concomitant changes in breast cancer risk

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Abstract
Among participants of the biennial Nijmegen breast cancer screening programme, we examined whether diminution of mammographic breast density lowered breast cancer risk. Post-menopausal breast cancer cases (n = 108), who had to have participated in all the five screening rounds prior to their diagnosis, were matched to 400 controls on year of birth and screening history. Controls had to be free of breast cancer at the time of the case's diagnosis. Changes in breast density were measured over a 10-year period, by a fully computerized method. Women in whom 5–25% or > 25% of the breast was composed of fibre-glandular density showed a threefold increased 10-year risk compared to women with 25% density the OR was 6.9 (95% CI = 2.1–22.9). In women with > 25% density initially, diminishing density was not clearly associated with lowering risk, which may be partly explained by the low number of women who decreased to n

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