Response of ligated intestinal loops in lambs to an enteropathogenic factor of Clostridium perfringens type A

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Abstract
Concentrated supernatant fluids from vegetative cultures and cell extracts from sporulating cultures of Clostridium perfringens type A, both of which had previously been found to cause diarrhea in lambs, were tested in ligated intestinal loops of lambs. The concentrated supernatant fluids had no detectable effect in the loops while the cell extracts caused extensive accumulation of fluid. Rabbit immune sera prepared against extracts from sporulating cells completely inhibited the activity of the cell extracts in the ligated loops.Vegetative cells, injected into ligated loops with fresh medium, sporulated in situ and caused fluid accumulation. This accumulation of fluid was not prevented by the immune sera prepared against extracts from sporulating cells.

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