The July 1999 heat wave in the Midwest was an event of relatively long duration punctuated by extreme conditions during its last 2 days. The intensity of the heat wave on 29 and 30 July rivaled that of the 1995 heat wave that killed more than 1000 people in the central United States. In 1999, however, the death toll was about one–fourth of this amount in the same region. The 1999 heat wave 2–day maximum apparent temperature was slightly less than during the 1995 heat wave at most Midwestern first–order stations. In addition, the 2–day peak was preceded by several hot days that allowed some short–term acclimatization to occur prior to the intense final days. In Chicago, conditions during the peak of the 1999 heat wave were very similar to those during the 1995 heat wave peak, especially the extreme nocturnal conditions of temperatures and humidity. Therefore, it seems unlikely that the reduction in the heat wave death toll in Chicago from about 700 in 1995 to 114 in 1999 is due solely to meteorolo... Abstract The July 1999 heat wave in the Midwest was an event of relatively long duration punctuated by extreme conditions during its last 2 days. The intensity of the heat wave on 29 and 30 July rivaled that of the 1995 heat wave that killed more than 1000 people in the central United States. In 1999, however, the death toll was about one–fourth of this amount in the same region. The 1999 heat wave 2–day maximum apparent temperature was slightly less than during the 1995 heat wave at most Midwestern first–order stations. In addition, the 2–day peak was preceded by several hot days that allowed some short–term acclimatization to occur prior to the intense final days. In Chicago, conditions during the peak of the 1999 heat wave were very similar to those during the 1995 heat wave peak, especially the extreme nocturnal conditions of temperatures and humidity. Therefore, it seems unlikely that the reduction in the heat wave death toll in Chicago from about 700 in 1995 to 114 in 1999 is due solely to meteorolo...