Uric Acid Metabolism in Normal Man and in Primary Gout

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Abstract
THE metabolism of uric acid in man, with special reference to its presumptive aberrations in gout, has been the subject of several excellent reviews in recent years, notably those of Seegmiller et al.,1 Sorensen,2 Talbott3 and Wyngaarden.4 The purpose of the present survey is to integrate into this body of knowledge a few fresh bits of information and also to offer certain reinterpretations of the data.Chemical and Biologic Characterization of Uric AeroUric acid (2,6,8-trioxypurine) owes its weakly acidic properties to ionization at N-9 (Fig. 1) in the physiologic pH range.5 The pKa of uric acid is 5.75, according . . .