THE INHIBITION OF GROWTH BY 1·2 : 5·6 DIBENZANTHRACENE AND OTHER AGENTS

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Abstract
1. Single injections of 5, 10, and 20 mg. 1·2 : 5·6 dibenzanthracene produce a prolonged inhibiting effect on the growth of young rats, and the effect produced varies as the dosage.2. Mercury in oil, bismuth salicylate in oil, and thallium acetate in single injections produce an immediate but transient interference with growth.3. Various non‐carcinogenic polycyclic hydrocarbons produce an immediate but transient interference with growth.4. Nearly half (21/48) of the animals injected with d.b.a. died within 64 days. Half the deaths (11/21) occurred between 40 and 64 days after injection.This work was made possible by a grant from the Medical Research Council for the maintenance of animals and laboratory expenses, and by a personal grant from the Cancer Control Organisation for South‐East Scotland. Thanks are also due to Dr. C. M. Scott for advice and assistance.

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