A NONINVASIVE METHOD FOR MONITORING THE EFFECTS OF INCREASED INTRACRANIAL-PRESSURE WITH NEAR-INFRARED SPECTROPHOTOMETRY

  • 1 January 1985
    • journal article
    • research article
    • Vol. 161  (2) , 145-148
Abstract
Two experiments were conducted to assess the feasibility of near IR spectrophotometry (niroscopy) to monitor directly the effects of increased intracranial pressure [ICP] on brain metabolism. ICP was increased in cats by subarachnoid infusion of a mock CSF solution. Cytochrome .alpha.,.alpha.3 redox state, deoxyhemoglobin, deoxyhemoglobin and cerebral blood flow were noninvasively and continuously monitored by niroscopy. The results of both experiments indicated that changes in ICP correlated with a reduction in cytochrome .alpha.,.alpha.3 redox state (P < 0.01), a decrease in the quantity of deoxyhemoglobin and cerebral flow (P < 0.01) and an increase in deoxyhemoglobin. The study results suggest that niroscopy has the potential for providing noninvasive and continuous data for assessing brain metabolic activity. The correlations obtained with simultaneous measurements of intracranial pressure make this an attractive method for application to those at risk for increased intracranial pressure.

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