SYNTHESIS OF N-ACETYL-MURAMYL-l-ALANYL-d-GLUTAMIC-α-AMIDE(MDP) OR -α-METHYL ESTER DERIVATIVES, BEARING A LIPOPHILIC GROUP AT THE C-TERMINAL PEPTIDE END
- 12 January 2009
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 14 (5) , 437-444
- https://doi.org/10.1111/j.1399-3011.1979.tb01954.x
Abstract
The synthesis of 9 lipophilic derivatives of N-acetyl-muramyl-L-alanyl-D-glutamic-.alpha.-amide (MDP) or -.alpha.-methyl ester, in which the .gamma.-carboxyl function of the D-glu residue is either esterified by a medium chain alcohol or substituted by an L-Ala residue esterified by a medium or long chain alcohol, is reported. A new method is described which easily allows one to obtain derivatives of MDP, bearing a free or substituted amino-acyl or peptidyl residue on the .gamma.-carboxyl function. These derivatives allow numerous biological studies of stimulation of specific and non-specific immune responses.Keywords
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