The pediatric nephrotic syndrome spectrum: Clinical homogeneity and molecular heterogeneity
- 19 July 2004
- journal article
- review article
- Published by Wiley in Pediatric Transplantation
- Vol. 8 (4) , 344-348
- https://doi.org/10.1111/j.1399-3046.2004.00179.x
Abstract
Abstract: Idiopathic nephrotic syndrome is the most common glomerular disorder of childhood. Recurrence of nephrotic syndrome immediately following renal transplantation is rapid, results in a high rate of graft loss, and represents the most severe form of nephrotic syndrome. This review discusses the molecular heterogeneity of pediatric nephrotic syndrome across the spectrum of disease activity. A schema is offered for a molecular approach to pediatric nephrotic syndrome, including immune‐mediated and structural/genetic factors.Keywords
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