THE METABOLISM OF SKELETAL MUSCLE UNDERGOING ATROPHY OF DENERVATION

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Abstract
A comparison was made of the sugar, lactic acid, O and CO2 content of the blood entering and leaving a denervated limb with that from a normal control limb. The [32] experiments were carried out on [14] dogs under local or amytal anesthesia at periods varying from 1/2 hr. to 14 weeks after denervation. Studies were made during rest, mild exercise, glucose administration, and after subcutaneous injection of adrenalin. The resplratory quotient (calculated from the difference in CO2 and O content of arterial and venous blood) of the denervated limbs was essentially the same as that of the normal control limbs and approximated that found for the entire animal. A denervated limb resembled a normal limb in the exchange of sugar and lactic acid between the tissue and blood stream. Apparently the presence of an intact nerve supply does not determine the mixture of foodstuffs oxidized by muscle, and skeletal muscle undergoing atrophy of denervation exhibits a metabolism qualitatively similar to that of normal muscle as far as can be determined by analysis of blood.

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