Effect of zinc on protoporphyrin induced photohaemolysis

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Abstract
Zn is readily inserted into protoporphyrin suspended in a salt-sucrose buffered solution or endogenously present in red cell hemolysate in erythropoietic protoporphyria. Red cells from healthy persons were incubated with metal-free protoporphyrin or Zn-protoporphyrin and irradiated with light at 360-470 nm. The photohemolysis was significantly less with Zn-protoporphyrin compared with that of the metal-free protoporphyrin. The results were discussed in relation to the possibility of using Zn as a photoprotective and hepatoprotective agent in erythropoietic protoporphyria.
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