Disseminated cytomegalic inclusion disease occurred in a burned adult. Two serum samples drawn during the first half of the patient's hospital course did not contain complement-fixing antibody to cytomegalovirus (CMV), which provided evidence in favor of a primary infection. A possible exogenous source of CMV could have been one or more of the 72 units of blood which the patient received. The patient had multiple generalized, opportunistic infections, including at least two types of fungus, in addition to CMV. Opportunistic mycotic and viral infections are being recognized with increasing frequency in burn patients. This may either reflect marked debility following severe thermal injury or be related to suppression of bacterial growth on the burn wound by topical antibacterial therapy.