Mutational specificity of 2-nitro-3,4-dimethylimidazo[4,5-f]quinoline in the lacI gene of Escherichia coli
- 1 March 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 14 (3) , 511-517
- https://doi.org/10.1093/carcin/14.3.511
Abstract
2-Nitro-3,4-dimethylimidazo[4,5-f]quinoline (NO2-MeIQ) is the nitro derivative of 2-amino-3,4-dimethylimi-dazo[4,5-f]quinoline (MeIQ), one of the food pyrolysis product mutagens and carcinogens. The mutational specificity of NO2-MeIQ was determined using the lacI system in an Escherichia coli strain, EE125, harbouring the plasmid pKM101. NO2-MeIQ acts as a direct-acting mutagen towards this strain, and induces a broad range of mutational alterations. At higher doses; G:C ↑ T:A transversions dominate the mutational spectrum. Complex mutations were also observed, and the involvement of the SOS system in the processing of the mutations induced by NO2-MeIQ is suggested.Keywords
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