Dopamine modulates the afterhyperpolarization in neostriatal neurones

31 January 1996

journal article
research article
Published by Wolters Kluwer Health in NeuroReport

Vol. 7 (2) , 454-456
https://doi.org/10.1097/00001756-199601310-00019

Abstract

Intracellular techniques were used to study the actions of dopaminergic D₁ agonists on the afterhyperpolarization (AHP) that follows action potentials in rat neostriatal neurones. Dopamine or Cl-APB (10 μM), or 1–10 μM 6-C1-PB all increased AHP amplitude. This effect was blocked by 1 μM SCH-23390, a D₁ antagonist, but not by 1 μM sulpiride, a D₂ antagonist. Both 500 μM dibutyryl cAMP and 5 μM BayK 8644 induced a similar AHP increase. BayK 8644 occluded the effect of agonists. The results suggest that the action of dopamine is mediated via the recently described protein kinase A enhancement of L-type Ca²⁺ channels. The results partially explain the decrease in firing frequency induced by dopamine and a possible site of antagonism with cholinergic modulation.

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