The Effect of 2-Pivalyl-1,3-Indandione on Body Lice, When Administered Orally to Rabbit Hosts

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Abstract
Laboratory expts. were conducted to determine the effect of tertiary butyl valone on Pediculus humanus corporis, when administered orally to rabbit hosts. Three rabbits were fed a diet of commercial rabbit pellets to which sufficient chemical was added so that the desired dose was contained in 50 g. of feed. The min. quantity required to prevent reproduction among lice feeding on the rabbits was about 0.15 mg./kg. At this dosage, young nymphs succumbed within 3 days but at a dosage of 0.125 mg./kg., about half the lice reached maturity and a few viable eggs were produced. The mortality for females was generally higher than among males when the lice were given only one blood meal on rabbits receiving 0.15, 0.175, and 0.2 mg. of 2-pivalyl-1,3-indandione per kg. Nymphs showed a decreasing mortality as they became older. The" blood of the rabbits remained toxic to the lice for only 3 days after feeding of the chemical was discontinued. One rabbit that had received varying quantities of 2-pivalyl-l,3-indandione over a period of 8 mos. died. No lesions definitely attributable to the chemical were found, although it is known to be toxic to warm-blooded animals.

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