Influence of Epinephrine on Vasoconstrictive Action of Organ Extracts.

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Abstract
Many protein fractions isolated from kidney, liver, and heart of hog, and from kidney and liver of dog and rabbit, inactive when perfused alone through the rabbit''s ear, become vasoconstrictive at varying degrees when combined with subthreshold quantities of epinephrine. In contrast, dialyzed saline extracts of fresh minced organs were inactive with and without addition of epinephrine. After freezing and thawing or prolonged dialyzation against distilled water, epinephrine addition resulted in some activity. 0.8 mg. of protein or protein mixture secured by continued fractionation of hog liver, and combined with subthreshold amts. of epinephrine, produced marked and long lasting vasoconstrictions.

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