Use of purified protein derivative to assess the risk of infection in children in close contact with adults with tuberculosis in a population with high Calmette-Guérin bacillus coverage

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Abstract
Household contacts To assess the use of purified protein derivative (PPD) and frequency of infection in children with high Calmette-Guérin bacillus (BCG) coverage who were recently exposed to TB. Cross-sectional study of 141 exposed household contacts Exposed children were younger and less up to date in their vaccination schedule than controls (P vs. PPD is a useful test to identify children infected with TB independently of whether they had received BCG or not. Children exposed to adults with TB are at high risk of infection. The risk of infection is associated with the intimacy of contact and the number of bacilli expectorated in sputum.