Experimental studies on mutagenic and carcinogenic effects of tobacco chewing

1 May 1985

journal article
research article
Published by Springer Nature in Zeitschrift für Krebsforschung und Klinische Onkologie

Vol. 109 (3) , 203-207
https://doi.org/10.1007/bf00390358

Abstract

The alcoholic extract of the chewing (Pandharpuri) variety of tobacco (Nicotiana tabaccum) was subjected to mutagenicity and tumorigenicity studies. The extract was found to be mutagenic in strain TA 98 of Salmonella typhimurium in the presence of S 9 mixture. It also induced 8 AZG-resistant mutation in V 79 Chinese hamster cells. Administration of tobacco extract to male Swiss mice by gavage or mixed with diet resulted in an increased incidence of lung/liver tumors. Further, an additive effect of tobacco extract and hexachlorocyclohexane on liver tumor induction was observed.

Keywords

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