SMALL COLONY VARIANT IN CANDIDA ALBICANS

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Abstract
Various techniques were used to attempt to alter the frequency of wild-type and small-type colonies in growing cultures of Candida albicans. Ultraviolet light and heat shocks were found to temporarily increase the occurrence of small colonies and several benzazoles were found to increase the number of large colonies. The alterations by the benzazoles was found to be only temporary, and brought about by an increase in the rate of growth of the small-type colonies. This benzazole action may be enhanced or inhibited by the addition of purines depending upon the applied concentration.