High‐Permeability Membrane Hemodialysis and Hernofiltration in Acute Hepatic Coma: Experimental and Clinical Results

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Abstract
A high-permeability polyacrylonitrile membrane was used for hemodialysis in pigs with induced liver ischemia and for acute treatment of 39 patients with fulminant hepatic failure. Measurements were made of amino acids and other relevant compounds; 9 patients survived. In long-term studies, the polyacrylonitrile membrane was used for hemofiltration in 10 clinical cases of fulminant hepatic failure and coma. Five patients, including 2 pregnant women, survived.