Effect of 2,4-Dinitrophenol on Replication of Poliovirus in HeLa Cells.

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Abstract
Polio virus was found to replicate in HeLa cells treated with critical concentrations of 2,4-dinitrophenol which markedly stimulated oxygen uptake and glucose utilization under aerobic conditions. The time required before a change in rate of respiration of infected cells became apparent was similar in absence or presence of DNP, indicating that this substance did not alter the latent period of virus synthesis. Apparently the uncoupling effect on aerobic phosphorylating systems is compensated for by increased glycolysis and the concomitant fixation of phosphorous by systems not effected by DNP.

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