Prolonged Severe Cholestasis Induced by Oxacillin Derivatives

Abstract
Tauris P, JØrgensen NF, Petersen CM, Albertsen K. (Department of Internal Medicine and Infectious Diseases, Marselisborg Hospital, University of Aarhus, Aarhus, Denmark.) Prolonged severe cholestasis induced by oxacillin derivatives.Two patients with osteomyelitis who developed reversible cholestatic jaundice during treatment with oxacillin derivatives are described. The clinical course as well as the biochemical pattern and the investigation of liver biopsy specimens enabled us to establish the diagnoses of drug‐induced canalicular and hepatocanalicular cholestasis.

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